about 45 seconds into a run everything starts to hurt, and it doesn't go away for the next 20-30 minutes of running...
I like the metaphor of 'running through life' because I can't think of any single action that makes me feel more like a corpse of organs and frantic electronic waves. Or as euphoric when its all done and body covered in sweat, mind in a daze, you've conquered some random numeric equation...